bruton tyrosine kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16730	Remibrutinib		BTK
	Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1 nM). Remibrutinib has the potential for Chronic urticar...		BTK
T9125	Tolebrutinib	PRN2246,SAR442168	BTK
	Tolebrutinib (PRN2246) is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively). It exhibits effi...		BTK
T14692	BMX-IN-1	BMX kinase inhibitor	BTK
	BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 ...		BTK
T1976	RN486		BTK
	RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).		BTK
T5138	BMS-986142		BTK
	BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).		BTK
T16157	MT-802		BTK , PROTACs
	MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).		BTK , PROTACs
T10625	IBT6A		BTK
	IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.		BTK
T36287	Pirtobrutinib		BTK
	Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to t...		BTK
T10626	(Rac)-IBT6A		Others , BTK
	(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.		Others , BTK
T6217	LFM-A13		PLK , JAK , BTK
	LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.		PLK , JAK , BTK
T2472	CGI-1746		BTK , Autophagy
	CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.		BTK , Autophagy
TQ0242	Fenebrutinib	GDC-0853	BTK
	Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).		BTK
T12542	Rilzabrutinib	PRN1008	EGFR , Others , HER , BTK
	Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).		EGFR , Others , HER , BTK
T5407	Branebrutinib	BMS986195	BTK
	Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family (IC50 <1 nM for BTK).		BTK
T9706	BTK inhibitor 17		BTK
	BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor 17 can be used in rheumatoid arthritis studies.		BTK
T14323	ARQ 531		BTK
	ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.		BTK
T2302	CNX-774	CNX 774	BTK
	CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).		BTK
T12317	Orelabrutinib	ICP-022	BTK
	Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).		BTK
T7584	Zanubrutinib	BGB-3111	BTK
	Zanubrutinib (BGB-3111) is an inhibitor of Bruton tyrosine kinase (BTK).		BTK
T9192	BIIB068		BTK
	BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.		BTK
TQ0230	BTK IN-1	SNS062 analog	BTK
	BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).		BTK
T10629	Btk inhibitor 2	BGB-3111 analog	BTK
	Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.		BTK
T4337	PCI 29732	PCI29732,PCI-29732	Others , BCRP , BTK
	PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.		Others , BCRP , BTK
T9705	TL-895		BTK
	TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and a Ki of 11.9 nM.		BTK
T3626	Acalabrutinib	ACP-196	BTK
	Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and pre...		BTK
T3024	Avitinib	AC0010	EGFR , JAK , BTK
	Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administrat...		EGFR , JAK , BTK
T1835	Ibrutinib	PCI-32765	Tyrosine Kinases , Src , BTK , Ligands for Target Protein for PROTAC
	Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
T2603	Spebrutinib	CC-292,LMK-435,AVL-292	Src , BTK
	Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity.		Src , BTK
T8636	Ibrutinib deacryloylpiperidine	IBT4A,5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine	BTK
	Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.		BTK
T12311	Tirabrutinib hydrochloride	ONO-4059 (hydrochloride),GS-4059 (hydrochloride)	BTK
	Tirabrutinib hydrochloride (GS-4059 (hydrochloride)) is a selective and novelBTK with IC50 2.2 nm inhibitor.		BTK
T6921	ONO-4059 analog	ONO-4059 analogue,ONO-WG-307,GS-4059 analog	Apoptosis , BTK
	ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.		Apoptosis , BTK
T9304	(S)-Sunvozertinib	N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008	EGFR , HER
	(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.		EGFR , HER
T13447	(R)-Zanubrutinib	(R)-BGB-3111	BTK
	(R)-Zanubrutinib ((R)-BGB-3111) is a selective inhibitor of Bruton tyrosine kinase (BTK).		BTK
T4413	Poseltinib
	Poseltinib is an orally active, selective, and irreversible Bruton's tyrosine kinase (BTK) inhibitor, exhibiting a half-maximal inhibitory concentration (IC 50) of 1.95 nM. It demonstrates 0.3, 2.3, and 2.4-fold greater ...

Compounds

Remibrutinib

T16730

Synonym: PRN2246,SAR442168

Target: BTK

BMX-IN-1

T14692

Synonym: BMX kinase inhibitor

Target: PLK, JAK, BTK

CGI-1746

T2472

Synonym:

Target: BTK, Autophagy

Target: EGFR, Others, HER, BTK

Synonym: SNS062 analog

Target: BTK

Btk inhibitor 2

T10629

Synonym: BGB-3111 analog

Target: BTK

PCI 29732

T4337

Synonym: PCI29732,PCI-29732

Target: Others, BCRP, BTK

Target: EGFR, JAK, BTK

Ibrutinib

T1835

Synonym: PCI-32765

Target: Tyrosine Kinases, Src, BTK, Ligands for Target Protein for PROTAC

Spebrutinib

T2603

Synonym: CC-292,LMK-435,AVL-292

Target: Src, BTK

Ibrutinib deacryloylpiperidine

T8636

Synonym: IBT4A,5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine

Target: BTK

Tirabrutinib hydrochloride

T12311

Synonym: ONO-4059 (hydrochloride),GS-4059 (hydrochloride)

Target: BTK

ONO-4059 analog

T6921

Synonym: ONO-4059 analogue,ONO-WG-307,GS-4059 analog

Target: Apoptosis, BTK

(S)-Sunvozertinib

T9304

Synonym: N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008

Target: EGFR, HER

(R)-Zanubrutinib

T13447

Synonym: (R)-BGB-3111

Cat No.	Product Name	Species	Expression System
TMPH-02271	BTK Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activatio...

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Recombinant Proteins